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Last Edited: 5/13/2009

Maternal Rh D Status, Anti-D Immune Globulin Exposure During Pregnancy, and Risk of Autism Spectrum Disorders
Written: 01/02/08

OBJECTIVE: The objective of the study was to investigate the association between maternal Rh D status, prenatal exposure to anti-D immune globulin, and the risk of autism in the offspring. STUDY DESIGN: Case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n = 400) were children with an autism diagnosis; controls (n = 410) were children without autism, randomly sampled and frequency matched to cases on sex, birth year, and birth hospital. Maternal Rh D status and anti-D immune globulin exposure were ascertained from prenatal medical records. RESULTS: No case-control differences were observed for maternal Rh negative status (11.5% vs 10.0%, P = .5) or prenatal anti-D immune globulin exposure (10.0% vs. 9.3%, P = .7). Risk of autism remained unassociated with maternal Rh status or prenatal exposure to anti-D immune globulins after adjustment for covariates. CONCLUSION: These data support previous findings that prenatal exposure to thimerosal-containing anti-D immune globulins does not increase the risk of autism.



Suggested Citation

  • Publication Types: Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. MeSH Terms: Adult Autistic Disorder/epidemiology* Case-Control Studies Female Humans Immunologic Factors Male Pregnancy Prenatal Exposure Delayed Effects/epidemiology* Preservatives, Pharmaceutical* Rh-Hr Blood-Group System/blood* Rho(D) Immune Globulin Risk Assessment Thimerosal* Substances: Immunologic Factors Preservatives, Pharmaceutical Rh-Hr Blood-Group System Rho(D) Immune Globulin Thimerosal Grant Support: U10/CCU920392/PHS HHS/United States